Abstract: The Next-Generation Dermal Filler: Nanofiber-Hydrogel Composite

INTRODUCTION: Soft tissue losses from aging, trauma, or congenital malformation affect millions of people each year. Injectable fillers are effective in providing soft tissue volumization for facial rejuvenation and reconstruction. The majority of dermal fillers are based on hyaluronic acid (HA) and rely on high concentrations of HA to provide adequate viscosity and temporary persistence. This results in poor cellular infiltration, inflammation, and granuloma formation. To address these deficits, we have developed a unique dermal filler based on a nanofiber-hydrogel composite with interfacial bonding that mechanically mimics native fat. The composite structure allows cellular infiltration while also enabling longer lasting restoration with less inflammation and fibrosis.